The I-440 ramp on I-65 N was closed Monday afternoon while police investigated a fatal crash.
Police said 61-year-old Robert Harris was driving his 2018 Lexus SUV north on I-65 when, for unknown reasons, he traveled off the road around 2 p.m. He then entered a grassy area without an attempt to brake and hit the concrete pillar that supports the Thompson Lane overpass.
Harris was transported to Vanderbilt University Medical Center, where he died.
Police said the 61-year-old was not wearing a seatbelt and there was no evidence of drug or alcohol use.