The children were once thought to have died in a house fire at their grandparent's home where they lived. The remains of the grandparents were found, however, the children's bodies were not located. They have been listed as missing ever since.
Sunday, family members wore shirts with the children's pictures on them and pled for new clues that might reveal their whereabouts.
"It would be our Christmas wish to hear their voices again," said the children's great aunt, Mary Lamb.
Lillie Buchanan shares the same wish.
Her grandson, Antonio Taylor, left home with a friend in 1999 and hasn't been seen since. He was 21 years old at the time.
"We want closure. It's been a long time for the family to go through what we've been through," said Buchanan.
Those gathered at the vigil said a prayer for the missing individuals, including Shelley Mook, a 24-year-old mother and beloved middle school teacher who disappeared in 2011. Her burned out car was later found in a field in Rutherford County.
Investigators have received tips in each of the cases but nothing has led them to the missing individuals.
Family members told Nashville's News 2 they haven't stopped searching and hope the public can provide new clues to help find them.