Fort Campbell will send around 4,800 troops to Afghanistan this winter.
Soldiers from the 2nd Infantry Brigade Combat Team and the 159th Combat Aviation Brigade of the 101st Airborne Division are scheduled to deploy.
The teams are among six combat groups that will rotate service overseas during the winter of 2013/2014.
Nearly 9,000 troops total are being deployed "in support of combatant commander's mission requirements," according to the Department of Defense.
No exact date for deployment was provided.