During the event Mayor McMillan, who battles MS, will receive the Hope Award, which is the highest honor for outstanding civic and community service.
"I have been so honored by the people at the MS Society and all the citizens of Clarksville and everyone across the state who has encourage me to continue on as my job as mayor even after being diagnosed," she told Nashville's News 2.
McMillan was sworn in as mayor in January of 2011 and became the first woman to serve as mayor of any Tennessee city with a population over 100,000.
"I care about the people of Clarksville so much and I want to make their lives better, so I am willing to do whatever it takes to continue on with this job," she said.
McMillan is also a member of numerous organizations and serves on several boards including Leadership Middle Tennessee and Cumberland Bank and Trust.
She earned her undergraduate and law degree from the University of Tennessee.